Medina is a city in and the county seat of Medina County, Ohio, United States. The population was 26,094 at the 2020 census. It lies about 3…Medina is a city in and the county seat of Medina County, Ohio, United States. The population was 26,094 at the 2020 census. It lies about 33 miles south of Cleveland and 23 miles west of Akron within the Cleveland metropolitan area.