Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 ...

How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

Guarding genes against damage is a crucial and complex job, so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different circumstances.

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

Entire sections of the chromosome where the repair had taken place were missing ... between the different versions of the ...

A new species of tardigrades with thousands of genes that become more active when exposed to radiation could help in devising ...

Unraveling DNA polymerase’s activity can help scientists better understand DNA replication and repair and explore how these processes fail and lead to diseases, such as cancer. “This finding [happened ...

Methylation of NEAT1 influences its secondary structure, crucial for DNA repair factor activation. Understanding NEAT1's role may lead to new treatments for tumors with elevated NEAT1 levels. Whenever ...

The trial, led by The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, involved 21 patients with advanced solid tumours with defects in various genes which help ...

catalysts by merging DNA repair with biorthogonal chemistry, paving the way for more efficient and versatile approaches to asymmetric catalysis. Enzyme catalysis, which uses biological proteins to ...