Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical ...

Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy ...

The study helps partly explain why: the metabolic enzyme IMPDH2 relocates to the nucleus of TNBC cells to assist in DNA repair processes. "IMPDH2 acts like a mechanic in the cell's nucleus, ...

Metabolic enzymes, typically associated with energy production, are now discovered to also play essential roles in the nucleus, such as orchestrating cell division and DNA repair. This breakthrough, ...

Studies suggest the cell is more interconnected than previously thought, opening up "exciting possibilities for science and medicine." ...

Fluorescent cell sorting has identified that these gambler cells exhibit ... The signaling molecule (p)ppGpp plays an ...

Molecular Cell, 2024. Francesca Mattiroli is a group leader at the Hubrecht Institute since January 2018. Her group investigates chromatin dynamics during DNA replication and repair. The Mattiroli ...

A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other ...

When tested in mice, the compound—named BBI-2779—shrank gastric tumors and prevented the cancer from developing resistance to ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.