The San Francisco 49ers (1-0) and the Minnesota Vikings (1-0) square off at U.S. Bank Stadium on Sunday, September 15, 2024. The 49ers and the Vikings play at 1 p.m. ET. NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

The 49ers squad is hitting the road for Week 2 to visit Justin Jefferson & Co. in Minnesota. The Vikings gave a dominant performance in their regular-season debut, blowing out the Giants, 28-6, on their home turf.

For Vikings vs. 49ers, the model is backing San Francisco to cover the spread. Kyle Shanahan's team looked like a repeat Super Bowl contender on Monday night as they dominated on both sides of the ball. Even if McCaffrey is unable to play in Week 2, the Niners have a more than capable back-up in Jordan Mason plus help from dual threat Deebo Samuel.

Week 2 of the NFL season began Thursday, Sept. 12, with the Buffalo Bills defeating the Miami Dolphins 31-10 in prime time. Dolphins quarterback Tua Tagovailoa left the game after sustaining what was at least the third concussion of his NFL career.

NFL Week 2 comes to a close with Monday Night Football as the Philadelphia Eagles host the Atlanta Falcons. Find out start time, where to watch or stream and more.

Quarterback C.J. Stroud and the Houston Texans face the Chicago Bears led by top draft pick Caleb Williams tonight in the Week 2 edition of Sunday Night Football.